Search from the Journals, Articles, and Headings
Advanced Search (Beta)
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...

انیس ناگی

ڈاکٹر انیس ناگی
حالات زندگی:
انیس ناگی پاکستان کے نامور محقق، افسانہ نگار، ناول نگار، نقاد، کالم نگار، مترجم اور شاعر تھے۔انیس ناگی 10 ستمبر 1939ء کو شیخوپورہ میں ابراہیم ناگی کے گھر پیدا ہوئے۔ ان کا خاندانی نام " یعقوب علی ناگی " تھا۔ انہوں نے مسلم ہائی اسکول نمبر 2 لاہور سے میٹرک کیا، گورنمنٹ کالج لاہور سے انٹر اور اورینٹل کالج لاہور سے ایم اے (اردو) کیا۔ جامعہ پنجاب سے اردو ادب میں ڈاکٹریٹ کی ڈگری حاصل کی اور گولڈ میڈل بھی حاصل کیا۔ تعلیم سے فراغت کے بعد وہ گورنمنٹ کالج لاہور اور گورنمنٹ کالج فیصل آباد میں تدریسی فرائض سر انجام دیے۔ گورنمنٹ کالج لاہور کے میگزین راوی کے مدیر بھی رہے۔ بعد ازاں انیس ناگی نے سول سروس کا امتحان پاس کیا اور ڈپٹی سیکرٹری ایجوکیشن سمیت مختلف سرکاری عہدوں پر فائز رہے۔ 1999ء میں وہ بورڈ آف ریونیو کے ارکان کی حیثیت سے ریٹائر ہوئے۔
ادبی خدمات:
انیس ناگی کا ادبی سفر بہت طویل ہے۔ انہوں نے شاعری، ناول، افسانہ، تنقید اور تراجم میں طبع آزمائی کی اور ہر صنف میں اپنی تخلیقی صلاحیتوں کو بہت احسن طریقے سے اجاگر کیا ہے۔ انہوں نے جذباتی نثر کی بجائے کارآمد نثر تخلیق کی اور شعوری طور پر ناول کو ادبی زبان کے برعکس عام بول چال میں قلمبند کیا۔ عام معاشرتی اور سیدھی سادی زبان میں قاری کے سامنے اپنی تخلیقات پیش کیں۔ ان کی جدید اردو نظم کو نہ صرف پاکستان بلکہ بیرون ملک بھی بہت پزیرائی ملی۔ وہ ساٹھ کی دہائی میں نئی شاعری کی تحریک کے نام سے سامنے آنے والے ان لوگوں میں شامل تھے جن کے لیے رائج شاعری کا روایتی پیرایہ اور اظہار ناقابلِ قبول تھا اور وہ شاعری میں نئے اظہار کو رواج دینا چاہتے تھے۔ نئی شاعری کی اس تحریک کے نمایاں لوگوں...

Muslim-Christian Relations in the Era of Prophet Muhammad: Review of Najrān Delegation’s Case in Modern Context

Muslim–Christian relations are as mature as Islamic history itself. Historical evidences state the first interaction of Muslims and Christians occurred in 5th year after nabuwwah (615 AD) when Muslims migrated to Ḥabshah (Abyssinia) and second contact was established after immigration of the Holy Prophet (PBUH) to Madinah. After getting socio-political stability in 8th hijrī (629 AD), Muhammad (PBUH) sent letters and ambassadors to different statesmen and religious leaders to spread the Islamic Mission and Message globally. One letter was also sent to the chief Bishop of Najrān. In response, the chief Bishop of Najrān accepted the invitation and personally came to meet the Prophet (PBUH) with his reputed delegation. The beloved Messenger (PBUH) warmly welcomed this delegation. As a result, the peace agreement was reached after some theological debate and discussion. Later on, throughout history, the relations between Muslims and Christians have been in situation of up and down. It’s also a fact that over the centuries, the Muslims-Christians relations had sometimes been one of enmity, sometimes one of rivalry, competition, and encounter. In spite of it, the Najrān’s delegation case has a historical significance in Muslim-Christian relations in the literature of both religions. Therefore, in this study efforts were made to explore the event of Najrān delegation as theological foundations for Muslim-Christian relations in times of the Holy Prophet (PBUH) and how can we get benefit from it in modern era. Moreover, this study perceives that the case of Najrān delegation was the first practical interaction between Muslims and Christians of that age. Hence, we could get benefit from it with its modern applications and interpretations. The analytical, comparative and historical approaches have been adopted in this study with qualitative paradigm. I compared and analysed the case in Islamic and Christian context and then gave recommendation for its application.

Mapping Genes Causing Syndromic and Non- Syndromic Human Hereditary Skin Disorders

Genetic defects in complex processes of embryonic development and postnatal maintenance of the skin and its appendages result in clinically and genetically heterogeneous group of skin disorders. Due to nonspecific presentation, variable clinical manifestations and highly overlapping phenotypes, the diagnosis of skin disorders is a challenging job for the clinicians and geneticists. However, recent advances in molecular biology technologies notably whole exome sequencing (WES) and microarray have incredibly accelerated identification of genes involved in inherited diseases. The research work, presented in this dissertation, described clinical and molecular characterization of seventeen families of Pakistani origin (A-Q) segregating various forms of syndromic and non-syndromic skin disorders. This included one with palmoplantar hyperkeratosis (A), three with nail disorders (B-D), one with xeroderma pigmentosum (E), two with non-photosensitive trichothiodystrophy and mitral regurgitation (F-G), three with different types of ichthyosis (H-J), two with epidermolysis bullosa (K-L), and five with different types of hair abnormalities (M-Q). In all seventeen families, combination of at least two or three techniques, including microsatellite/SNP genotyping and Sanger/Exome sequencing, led to the establishment of linkage on human chromosomes and detection of potential disease causing variants in different genes. This included fourteen novel variants in 13 different genes (SLURP1, SLCO2A1, ERRC5, MPLKIP, KRT83, ALDH3A2, ABHD5, PLEC, BTAF1, C3orf52, MTUS1, SGSM1, DCAF1) and previously reported three variants in 3 genes (RSPO4, FZD6, KRT14). Disease causing variants, identified in six genes (KRT83, SLCO2A1, BTAF1, MTUS1, C3orf52, SGSM1), are the first report of involvement of such genes in causing skin disorders. Pathogenicity of disease causing variants were tested and verified by various bioinformatics tools (SIFT, PolyPhen, MutationTaster, MutationAssessor, GERP++, phyloP). Non-polymorphic nature of the variants was validated by screening large number of ethnically matched control individuals and by searching various databases. In a couple of cases, qPCR was used to monitor effect of the variants on expression of other genes. In addition, where necessary, protein modelling studies were Abstract Mapping Genes Causing Syndromic and Non-Syndromic Human Hereditary Skin Disorders XIV performed to identify location of the mutations in the protein and its possible effect on structure and functions of the protein. The work presented in the dissertation resulted in the following publications. 1. Shah K, Ansar M, Khan FS, Ahmad W, Ferrara TM, Spritz RA (2017). Recessive progressive symmetric erythrokeratoderma results from a homozygous loss-of-function mutation of KRT83 and is allelic with dominant monilethrix. Journal of Medical Genetics 54: 186-189. 2. Shah K, Ferrara TM, Jan A, Umair M, Khan S, Ahmad W, Spritz RA. Homozygous SLCO2A1 translation initiation codon mutation in a Pakistani family with recessive isolated congenital nail clubbing (ICNC) (2017). British Journal of Dermatology. doi: 10.1111/bjd.15094. 3. Shah K, Ali RH, Ansar M, Lee K, Chishti MS, Abbe I, Li B, Smith JD, Nickerson DA, Shendure J, Coucke PJ, Leal SM, Ahmad W (2016). Mitral regurgitation as a phenotypic manifestation of nonphotosensitive trichothiodystrophy due to a splice variant in MPLKIP. BMC Medical Genetics 17: 13. 4. Shah K, Nasir A, Shahzad S, Khan S, Ahmad W (2016). A novel homozygous mutation disrupting the initiation codon in the SLURP1 gene underlies mal de Meleda in a consanguineous family. Clinical and Experimental Dermatology. 41: 675-679. 5. Raza SI, Navid AK, Noor Z, Shah K, Dar NR, Ahmad W, Rashid S (2017). GLY67ARG substitution in RSPO4 disrupts the WNT signaling pathway due to an abnormal binding pattern with LGRs leading to anonychia. RSC Advances 7:17357- 17366. 6. Shah K, Mehmood S, Jan A, Abbe I, Ali RH, Khan A, Chishti MS, Lee K, Ahmad F, Ansar M, University of Washington Center for Mendelian Genomics, Nickerson DA, Bamshad MJ, Coucke PJ, Santos‐Cortez RL, Spritz RA, Leal SM, Ahmad W (2017). Sequence Variants in Nine Different Genes Underlying Rare Skin Disorders in Ten Consanguineous Families. International Journal of Dermatology (Under Review). 7. Ahmad F, Shah K, Muhammad D, Basit S, Wakil SM, Umair M, Ramzand K, Ahmad W (2017). Novel autosomal recessive LAMA3 and PLEC1 mutations underlie non-hertz junctional epidermolysis bullosa and epidermolysis bullosa simplex with Abstract Mapping Genes Causing Syndromic and Non-Syndromic Human Hereditary Skin Disorders XV muscular dystrophy in two consanguineous families. Clinical and Experimental Dermatology (Under Review). 8. Shah K, Jan A, Ahmad W, Umair M, Irfanullah, Basit S, Ahmad W. A novel start loss variant in DCAF17 underlies Woodhouse-Sakati Syndrome phenotypes in a large consanguineous family (In Preparation). 9. Shah K, Umair M, Ahmad F, Ali G, Nawaz G, Jhon P, Ferrara TM, Spritz RA, Ahmad W. A heterozygous missense sequence variant in BTAF1 gene miss-regulate transcription and results in progressive patchy hair loss from the scalp (In Preparation). 10. Shah K, Ali G, Jhon P, Irfanullah, Ahmad F, Basit S, Ahmad W. C3orf52 is a probable candidate gene for autosomal recessive hypotrichosis in large Pakistani family. (In Preparation). 11. Shah K, Hussain S, Raza SI, Basit S, Ahmad W. Missense sequence variant in SGSM1 gene underlies unexplored phenotypes of hypertrichosis, macrocephaly, facial deformities, cardiac and urinary defects in Pakistani kindred. (In Preparation). 12. Shah k, Irfanullah, Ahmad F, Umair M, Basit S, Ahmad W. Complete hair loss in large consanguineous Pakistani family results from mutation in MTUS1 gene in a large consanguineous family. (In Preparation).
Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

Join our Whatsapp Channel to get regular updates.