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رشید احمد صدیقی

آہ! رشید احمدصدیقی
ابھی مولانا عبدالماجد دریابادی کی وفات کا غم تازہ ہی تھا کہ اردو زبان کے ایک اور صاحب کمال صاحب طرز اور صاحب فن ادیب اور انشاء پرداز یعنی یگانۂ روزگار، فخر مسلم یونیورسٹی علی گڑھ درمایۂ ناز فرزند شیراز ہند جناب رشید احمد صدیقی کی رحلت کی خبر ملی۔
دل سے لپٹ لپٹ کر غم بار بار رویا
وہ مڑیاہو ضلع جونپور کے رہنے والے تھے، علی گڑھ میں چھ سال تعلیم پائی، یہاں کے شعبۂ اردو کے صدر کی حیثیت سے سبکدوش ہوئے تو یہیں کے ہوکر رہ گئے، اس کی روایات کے رازداں، اس کی حمیت کے دیدباں، اس کی عزت کے نگہبان اور اس کی آبرو کے پاسبان بن کر ساری زندگی گزاری، وہ علی گڑھ مسلم یونیورسٹی کو ایک اہل دل مسلمان نقاش اور مصور کا شاہکار سمجھتے رہے، سیاحوں کو جو دل آویزی اور رعنائی اجنٹا اور ایلورا میں نظر آتی ہے، وہی ان کو گھر بیٹھے مسلم یونیورسٹی میں نظر آتی رہی، شاہجہاں مثمن برج میں بیٹھ کر تاج محل دیکھا کرتا، پھر اسی برج میں اس نے ایک چھوٹا سا شیشہ نصب کرا رکھا تھا، جس میں تاج محل کا پورا عکس پڑتا رہتا، رشید صاحب کے لئے علی گڑھ میں ان کا مکان ان کا مثمن برج تھا، جس کے اندورونی حصہ میں ایک خوبصورت لہلہاتا سبزہ زار تھا، اس کے بیرونی حصہ میں طرح طرح کے گلاب کے پودے لگے رہتے تھے، یہیں سے اپنے شیشہ دل میں اپنے ذہن کے تاج محل یعنی مسلم یونیورسٹی کو دیکھ کر خوش ہوتے رہتے، اب اسی تاج محل کے اندر مدفون ہیں، جس کی سرزمین نے ان کے جسدخاکی کو نہیں بلکہ مسلم یونیورسٹی کے نشاط روح، سوزسینہ اور دل بے قرار کو بڑے شوق سے اپنی آغوش میں لے لیا ہوگا، وہ جاچکے مگر اپنی...

حروف مقطعات کے حوالے سے مستشرق نولڈ یکے اور آٹو لوتھ کی آراء کا تجزیاتی مطالعہ

Mystical letters are among the miracles of Quran. These mystical letters are present at the start of Quranic Surah’s (Chapters). These are among the mutashabihat (Analogies) of Quran. Muslim scholars tried to define their meanings. Like other aspects of Quran and Hadith orientalists talk about mystical letters of the Quran. This article analyses the theories of Noldeke and Otto Loth regarding mysterious letters of Quran. What are their views about mystical letters of the Quran? Are their views according to the Islamic point of view of mystical letters? What are the deviations and differences as compared to traditional Islamic point of view of mystical letters? This research has been analytical by nature, both qualitative and analytical methods have been implemented.  Analyses of the views of both of the scholars in the light of traditional Islamic concept of mystical letters, shows that Orientalists including Noldeke and Otto Loth thought that mystical letters are not the part of revelation. According to them these are the names of the sources from which different chapters of the Quran had been taken during its compilation. These are on the same pattern as mystical letters are present in the Jewish books. Holy Prophet had copied them. The present study argues that Quran being the book of Lord is unchanged and mystical letters are a part of it. It is further highlighted that even some orientalists argue that the opinion of Noldeke and Otto Loth is not correct.

Genotypes of Human Papilloma Virus and Identification of Prospective Protein Biomarkers in Oral Rinse from O Ral Squamous Cell Carcinoma

Background: Oral cancer is the second preeminent malignancy in Pakistan after breast cancer, ascribed to widespread use of numerous perilous chewable tobacco formulations. The Human Papilloma Virus (HPV) has come forward as a new malefactor of malignant and pre malignant oral lesions. HPV related oral squamous cell carcinoma (OSCC) constitute an epidemiological, molecular and clinical distinctive subset of oral cancer. Regardless of the HPV status being related with molecular and clinical differences, all oral cancers are managed equally. Proteomic studies may help to understand the differences between HPV+VE and HPV-VE OSCC and let us to develop biomarkers for early detection, recurrence and prognosis leading to identification of therapeutic targets which will further initiate precisional treatment based on the biology of tumors. This study was designed to determine the association of HPV high-risk genotypes 16/18 in oral mucosa of chewable tobacco users and OSCC as well as identification of proteins in Oral rinse of OSCC patients with and without HPV with major focus on search for prospective tumor biomarker for HPV related OSCC. Methods: A case control study was designed with 100 OSCC patients and 200 controls. Persons addicted to chewable tobacco formulations such as gutka, pan, betel nut and naswar with or without oral lesions, having no delirious conditions were included. DNA from oral rinse of 300 subjects was taken. Samples were analysed by both conventional and real time PCR using “HPV consensus Gp5+/Gp6+ and HPV 16, 18 specific primers”. After PCR analysis, a random subset of 75 subjects was selected: 25 each of HPV +IVE OSCC, HPV –IVE OSCC and non- tobacco chewers. The peptides were separated by nanoflow liquid chromatograph system coupled online to LTQ-Orbitrap Velose mass spectrometer using a nanoelectrospray ion source (Thermo Scientific, Schwerte, Germany). Enrichment and protein–protein interaction (PPI) network analysis of the identified proteins was performed using FunRich: Functional Enrichment analysis tool version 3.1.3. HPV rates and types were compared between controls and OSCC and oral habits associated and non-associated OSCC samples by Chi-square test. Odds ratios (ORs) and 95% Confidence intervals for HPV and types were obtained by univariate and multivariate analysis. Posterior error probability (PEP) was calculated using Bayesian statistics as a probability of false hit using the peptide identification score (s) and length of peptide. Gene ontology (GO) functional categories, significant interactions and pathways associated with datasets were identified by using the hypergeometric test and pvalue correction with the BH and Bonferroni tests. In all statistical analysis, only p-value <0.05 was considered significant. Results: Out of 300 persons, 74/300 (25%) were found to be infected with HPV: “46/100(46%) from cases and 28/200(14%) from controls”. 26(35%) were infected by “both HPV 16/18 (23(50%) from cases and 3(12%) from controls”. Persons who were infected with HPV 16&18 had higher chances to develop OSCC as compared to those who didn‟t have HPV 16/18 (AOR: 21.4, 95% CI: 5.73 – 80.8). A total of 1995 proteins from HPV +ive OSCC (995), HPV –ive OSCC (816) and control samples (184) respectively were identified. Pairwise comparison revealed 37% of HPV +ive OSCC proteins were also present in HPV –ive OSCC samples whereas HPV-ive and HPV +ive OSCC share 18.6% and 17.1% of control proteins respectively. The 7-10 differentially expressed proteins from 74 secretory proteins in HPV +IVE OSCC were observed associated with 10 fold enriched pathways related to viral mRNA translation. The ribosomal proteins (RPS20, RPLP1, RLP0, RPS26, RPL12, RPS28 and RPL3) and glycosylated proteins were related to this pathway. Conclusion: The exposure to high risk strains of Human papilloma virus (16/18) in combination (p < 0.001, Adjusted odds ratio; 21.42) can be cause of development of OSCC. Chewing tobacco may be the cause of HPV transmission in the oral squamous cells through rough mucosa (p < 0.0001, Adjusted odds ratio; 11.85). To best of our knowledge, identification and interaction of secretory proteins of HPV +IVE OSCC are reported for the first time. The extensive ribosomal protein variations and their interaction in viral mRNA translation pathway may designate them as the potential biomarker for HPV +IVE OSCC. The protein level expression of RPLP1 and its involvement in OSCC may have been explored for the first time.
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