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مولانا محمد منظور نعمانی

مولانا محمد منظور نعمانی
گزشتہ مہینے کا معارف اشاعت کے مرحلے میں تھا کہ یہ افسوسناک خبر ملی کہ مولانا محمد منظور نعمانی ۴، ۵؍ مئی کی درمیانی شب میں انتقال فرماگئے۔ انا ﷲ وانا الیہ راجعون۔
اس قحط الرجال میں مولانا جیسے حکمت دین سے واقف صاحب فہم و بصیرت اور مدبر عالم، قوم کے درد مند مصلح اور ملت کے ہمدرد و غم گسار کا اٹھ جانا کس قدر المناک سانحہ ہے۔
مولانا ایک عالم و مصنف اور صاحب سلوک و عرفان بزرگ ہی نہ تھے بلکہ زمانے کے نبض شناس، وقت کے تقاضوں اور حالات سے باخبر اور عاقبت بیں بھی تھے جن کا عمل اس پر تھا کہ:
نکل کر خانقاہوں سے ادا کر رسمِ شبیری
کہ فقرِ خانقاہی ہے فقط اندوہ و دل گیری
وہ مذہبی، اصلاحی، قومی، ملی، تعلیمی اور اجتماعی جدوجہد کے ہر محاذ پر سرگرم اور متحرک دکھائی دیتے تھے، انہیں مسلمانوں کی موجودہ پستی و زبوں حالی کا پوری طرح احساس بھی تھا اور وہ اس کے ازالے کے لیے نہایت فکر مند بھی رہتے تھے، آزاد ہندوستان میں جن مسائل نے مسلمانان ہند کی زندگی تلخ اور مکدر کر رکھی ہے، ان پر شور و غوغا مچانے لچھے دار باتیں اور دھواں دار تقریریں کرنے اور پُرجوش تحریریں لکھنے والے تو بہت سارے لوگ ہیں لیکن ان پر مولانا کی طرح تڑپنے، بے چین ہوجانے، درد و کرب خلش و اضطراب میں مبتلا ہونے والے بہت کم لوگ ہیں، وہ مسلمانوں کی فلاح و بہود کے لیے دعا و مناجات میں بھی مصروف رہتے تھے اور ملک کے گوشے گوشے کی خاک بھی چھانتے رہتے تھے، ان کے گریہ شب اور دعا ہائے سحر گاہی سے گھبرا کر ابلیس بھی یہ کہتا رہا ہوگا کہ ؂
خال خال اس قوم میں اب تک نظر آتے ہیں وہ

معاصر نظام ہائے معیشت میں تقسیم دولت کے تصورات کا تقابلی جائزہ

One of the core issues in contemporary economic trends is the fair and just distribution of wealth into the society. In this research, a comparative study of ‘distribution of wealth’ in Capitalism, Communism and Islam has been conducted. Qualitative research method is adopted for the analysis of data. The review of literature reveals that central ideas of Capitalism, Communism and Islam are ‘liberty’, ‘equality’ and ‘justice’ respectively. After evaluating the basic infrastructure, methodological framework and practical consequences of these three systems, it has been established that Capitalism and Communism have badly failed in maintaining fair distribution of wealth. Both (Capitalism and Communism) enhanced global inequality which could be assessed from the present economic condition of world as half the world’s wealth is now in the hands of just 1% of the population. On the other hand, Islam has ensured the just distribution of wealth by taking two revolutionary steps: by giving 18 compulsory and 6 optional commandments about circulation of wealth and by overruling all means of hoarding. Moreover, unlike Capitalism and Communism, Islam has given special instructions to distribute wealth among poor, disable, and helpless persons of society who are incapable of participating in the process of production. These measures promote peace and prosperity in society and reduce the ratio of poverty. In the light of above findings, it is concluded that only Islamic economic system can guarantee the just and fair distribution of wealth. It is, therefore, recommended that Islamic countries should implement the Islamic economic system in order to get rid of economic instability.

Mutagenesis for Hyper Production of Streptokinase from Streptococcus Equisimilis and Comparative Sequence Analysis of Sk Gene

Streptokinase (SK) is protein excreted by strains of β-hemolytic Streptococci. It is applied as treatment of life-threatening diseases thrombosed arteriovenous shunts, and thromboembolism. Streptokinase is naturally produced by several bacterial strains especially Streptococci. In connection with its broad application in the field of medicine, there is an urgent need to search for methods of its hyper production. Present study aimed at SK hyper production by mutagenesis of S. equisimilis strain. The wild bacterial strain S. equisimilis was subjected to random mutagenesis (UV irradiation and Ethidium bromide) for enhanced streptokinase production. The modified strain was assessed for the activity of streptokinase. The mutant S. equisimilis UV6 showed the maximum SK production and activity. By standardizing the effects of different factors like substrate (CSL), carbon source, salt concentration, temperature and pH an optimum fermentation protocol for SK production was established. The higher SK production was observed in mutant strain UV6 601 U mL-1 with increased activity up to 400 %. The SK was purified and its kinetics data indicated improved activity as its Km value was low as compared to wild SK. The SK gene from mutant UV6 was amplified and cloned in E. coli using pTZ57R/T vector. The gene was sequenced and compared with the wild SK gene to check the genetic difference between wild and mutant strain. In our study, the comparative sequence analysis revealed 26 point mutations, among these 3 were transitions (A to G) while the remaining 23 were transversions (A/G to C/T) in coding region of sk gene. Moreover, 3 amino acid deletions at the C terminal region of SK protein were predicted due to non-sense mutation in coding region (resulting in a stop codon after residue 437). The activity of any protein is direcly linked with amino acid composision. in our studies, the in-silico analyses predicted that amino acid residues at position 22, 62, 64 and 80 could be accountable in SK hyperactivity.
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