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المدد

المدد
(ارادھنا)
زندگی بھی، موت بھی تو دیتا ہے
موسموں کے راستے سنوار کر۔۔۔!
ابابیلوں ، بلبلوں اور کبوتروں کو بھیجتا ہے
اے عشق۔۔۔!
پتھروں کو موم کرتے ہوئے بیاباں کو لالہ زار کرنے والے
میں تجھے سبز پتوں پر خط لکھ کر۔۔۔!
لذتِ حقیقت میں ڈوبے چشموں کا۔۔۔،
طواف کرنے والی ہوائوں کے سپرد کروں
تیرے زائروں کی ۔۔۔!
صبح و شام خانقاہی دیواروں کو چومتا پھروں
تو تاثیرِ وصل کی انتہا۔۔۔
تو جوازِ ہجر کا مدعا
خواب کو جھنجھوڑتی ۔۔۔تعبیر کی رگوں میں دوڑتی وفا
اے شافی۔۔۔!
تو ہی بیمار کرتا ہے۔۔۔ تو ہی شفا دیتا ہے
اے خالقِ ارض و سما۔۔۔ اے طبیب ِ کون و مکاں۔۔!
میرا وسیلہ ہے خیر الوریٰ۔۔۔ المد دالمدد۔۔!
یا محصی ، یا محیطُ۔۔۔ المد دالمدد

میں بہلول کی باتیں اطمینان سے سنتا رہا کیونکہ اس کی باتوں میں کہیں کہیں نثری نظم کا اسلوب خوب صورت انداز میں نظر آیا تھا۔ وہ سامنے والے شخص کی فکر آلود سوچ کو معنویت کے ساتھ ، شفق کی تعلق داری میںلے آنے کا ماہر نظر آتا تھا۔ اسی لیے میں نے اپنے قیام کوطویل کرنے کا سوچا ۔ شاید وہ میری سوچ کو پڑھ چکا تھا۔ اسی لیے وہ میرے بولنے سے پہلے بول پڑا۔
اُس نے میری طرف دیکھتے ہوئے کہا۔۔۔خوشبو قید نہیں ہو سکتی۔ شاخیں ہوں گی تو پھول کھل سکے گا۔ بصورتِ دیگر صرف اک بیج ہے جس میں ساری دنیا قید ہے۔ اگر بیج کو سازگار موسم ، زمین ، روشنی اور پانی ملے گا تب ہی وہ روشنی، ہوا کے ساتھ پرندوں کو اپنی طرف بلانے کے قابل ہو گا۔ اسی لیے میں ایک جگہ رہ نہیں سکتا۔ آج ہوائوں کے ساتھ سورج سے باتیں کر رہا ہوں۔۔۔کل نہ جانے کہاں۔۔۔ستاروں کے ساتھ سرگوشیاں کرتے ہوئے، کس حالت میں پڑا...

خواتین كی ملازمت تعلیمات اسلامی كی روشنی میں

Women employment is a practical issue of the modern age. It is adopted by almost all the nations and countries of the world. In the western countries rights of women including employment, trade, property, education etc were recognized after the efforts ofWomen Liberation Movement. However, in Islam these were declared their basic rights since the first day. A western woman is bound to earn her livelihood as it is not the duty ofa western man to provide her basic needs. However, in Islam a woman is legally protected for the provision of all her basic needs and it is the duty of her father, brother, husband and son to provide these to her. Islam permits a woman to do a job or carry out trade activities and earn money subject to some conditions. These may be carried out by the permission of her husband, father, etc. Besides employment, a woman should perform her obligations at her home and family, which is her basic duty. She must be careful about her husband and children rights. She must observe Hijab and abstain from mixing with non-mehram men and should follow other social teachings of Islam. Wealth earned by her is considered her property and she can spend it any way at her discretion. Study of Islamic History revealed that many of the wives of the prophet (Sallalla ho alaihe wassalam) and Sahabiyat (RA) carried out business activities and performed other jobs and thus earned money. They spent it to assist the Prophet's noble cause and to assist their husbands and to care their children. These activities were considered authorized and endorsed by the prophet (Sallalla ho alaihe wassalam)

Linkage Analysis of Pakistani Families With Autosomal Recessive Retinitis Pigmentosa

Over the past decades progress in the field of molecular genetics has had an immense contribution to the better understanding of hereditary diseases. Hereditary retinal disorders are a group of diseases that affect the normal function of retina leading to partial or complete loss of eye sight. Depending upon the type and severity of the disease, loss of vision may occur suddenly or gradually. Despite the age of onset and symptoms, eye diseases generally affect the overall quality of life in the affected individuals of all races, cultures and ethnicities and thus remained an active area of research in the past and will be explored in the future as well. The current study focused on the genetic analysis of eight consanguineous Pakistani families (A-H) with multiple members suffering from autosomal recessive RP or retinal dystrophies. These families were enrolled from different rural villages of Pakistan including Punjab, Khyber PakhtunKhwa and Sindh provinces. Clinical data of the affected members of the families were obtained and diagnosis of RP was made after ophthalmic assessment by local ophthalmologist. Physical evaluations ruled out presence of extraocular phenotypes. Blood samples were collected from available members of families and genomic DNA was isolated for use in genetic analysis. Initially all collected families were tested by STS based homozygosity mapping which result in the mapping of family B to chromosome 16. Remaining seven families were subjected to SNP based genome scan which revealed their mapping to different genomic regions. Further follow up of these seven families led to the identification of three novel muta-tions; (c.244- 2A>C) in C8ORF37 (Family C), (c.786delT) FAM161A (Family D) and (g.[152634_42094] delins A) LCA5 (Family F) genes. However mutation analysis of ZNF513, C2ORF71, FAM161A, VSNL1 genes in family A and CLN3 gene in family B did not identify any pathogenic variation. Two families (Family E and H) with multiple homozygous regions and a third family (i.e family A) underwent RD panel based next generation sequencing which only resulted in the identification of a known c.1600G>A in family E in TRPM1 gene. Although we identified two heterozygous variants (c.5653 A>G and c.14662 A>T) in USH2A gene in family A by RD panel sequencing but these variants did not segregate with the disease phenotype in this family. The splice site mutation (c.244 -2A>C) identified in family C was further analyzed with a minigene assay which confirmed the loss of splice acceptor site and the activation of Linkage Analysis of Pakistani Families with Autosomal Recessive Retinitis Pigmentosa xvi Abstract cryptic splice site in exon 3. Sanger sequencing of the cDNA also confirmed the activation of the cryptic splice site within exon 3 which result in the deletion of 22 nucleotides from the RNA. This 22 nucleotide deletion probably results in the frameshift and premature truncation of the protein. DNA walking was used to identify the large LCA5 deletion in family F. Sanger seuencing of PCR products obtained with DNA walking kit revealed a large homozygous deletion of 110540 bps (g.[152634_42094] delins A) in the LCA5 gene. This deletion is predicted to affect the binding site for the basal transcriptional apparatus therefore disrupts the transcriptional regulation and normal gene activation. Family G showed a recurrent mutation c.25G>A in the NMNAT1 gene. While RD panel NGS identified a recurrent missense mutation c.1208G>A, (p.Arg403Gln) in exon 11 of the CNGB3 in family H which did not segregate with the disease phenotype in the family. As this family has been clinically diagnosed with retinitis pigmentosa the CNGB3 variant does not segregate with the disease phenotype therefore negates the disease causative nature of the variant in this family. Families that did not link to any of the known genes/loci by conventional sequencing techniques may have the potential to link to novel genes involved in the pathogenesis of retinal dystrophies. Whole exome sequencing or whole genome sequencing may be implemented to determine the underlying genetic factors for families A, B and H. Linkage Analysis of Pakistani Families with Autosomal Recessive Retinitis Pigmentosa xvii Abstract This study resulted in one publication, · Ravesh and El Asrag et al., 2015. Novel C8orf37 mutations cause retinitis pigmentosa in consanguineous families of Pakistani origin Two manuscripts submitted and currently under review · Ansar and Ravesh et al., 2015. Detection of Novel Mutations Causing Autosomal Recessive Retinitis Pigmentosa in Pakistan · Ravesh et al., 2015. DNA walking reveals a large deletion of LCA5 in a consanguineous family from Pakistan Abstracts Presented in International Conferences · Ravesh Z, Weisschu N, Wissinger B, Ansar M. (2015): Molecular genetic analysis of Hereditary Retinal Dystrophies in Consanguineous Families from Pakistan. (Asia ARVO 2015, Feb 16 - 19, Yokohama, Japan). · Ravesh Z, Weisschu N, Reuter P, Bonin M, Ansar M, Wissinger B. (2015): Molecular genetic analysis of Autosomal Recessive Retinitis Pigmentosa & Leber congenital amaurosis in Pakistani Population (25th Annual Meeting of the German Society of Human genetics, ESSEN 2014).
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