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دودھ پلائی والی پہلی خاتون

آپ ﷺ کی ولادت سے سیدہ آمنہ ؓ کا گھر بقعہ نور بن گیا ۔ عثمان بن العاص ؓکی والدہ فاطمہ ؓ کہتی ہیں کہ میں شب ولادت سیدہ آمنہ ؓ کے پاس تھی ‘ میں نے گھر میں جس طرف بھی نظر دوڑائی مجھے نور ہی نور نظر آیا ۔ صاحب سید الوریٰ بحوالہ علامہ زرقانی بیان کرتے ہیں کہ شفاء بنت عوفؓ جو شب ولادت سیدہ آمنہؓ کے پاس تھیں ‘ کہتی ہیں ’’ میرے لیے مشرق و مغرب روشن ہو گئے ۔‘‘ یہ تمام انوار زمین پر دیکھے گئے جب کہ آسمان سے بھی نور کی برسات ہو رہی تھی ۔ اس منظر کو فاطمہ ؓ یوں بیان کرتی ہیں ’’ میں نے ستاروں کو دیکھا کہ وہ جھکے پڑتے تھے اور مجھے یوں لگتا تھا کہ مجھ پر گر پڑیں گے‘‘ ۔ مزید بحوالہ طبقات ابن سعد اور البدایہ و النہایہ لکھتے ہیں کہ خود سیدہ آمنہ ؓ فرماتی ہیں جب وہ مجھ سے منفصل ہوا تو اس کیساتھ ایک ایسا نور ظاہر ہوا ‘ جس سے مشرق و مغرب روشن ہو گئے ۔ ‘‘ پھر با حوالہ زرقانی ‘ سیرت حلبیہ اور سیرت ابن ہشام لکھتے ہیں ’’ میں نے اس ولادت کی رات کو ایسا نور دیکھا جس کی وجہ سے شام کے محلات ر وشن ہو گئے۔ اور میں نے انھیں دیکھ لیا ۔‘‘
یہاںسوال پیدا ہوتا ہے کہ زمین و آسمان منور ہو گئے ۔ انوار کی برسات کا منظر بی بی آمنہؓ ، فاطمہؓ اور شفا ء کے علاوہ کسی اور کو کیوں نظر نہیں آیا؟ اس کا جواب یہ ہے کہ اللہ تعالیٰ کی مشیت ہے کہ جو چیزیں اللہ تعالی ٰصرف مخصوص لوگوں کو دکھانا چاہے وہ تمام چیزیں حقیقتاََ موجود ہونے کے باوجود عام لوگوں کی نگاہوں سے پوشیدہ رہتی ہیں ۔ قرآن مجید میں...

IMPLEMENTASI BLENDED LEARNING DALAM MATA KULIAH ULUMUL QURAN PADA PASCASARJANA UNIVERSITAS ISLAM NEGERI ALAUDDIN MAKASSAR

This study aims to see the implementation of blended learning in Ulumul Qur'an courses at uin Alauddin Makassar Postgraduate. The method used in this study uses a type of qualitative research related to the implementation of Blended Learning Courses Ulumul Qur'an at the Postgraduate UIN Alauddin Makassar. The results showed that: (1) the description of the model of implementation of the implementation of the study blended Ulumul Qur'an courses at the Postgraduate UIN Alauddin Makassar using a dual-system that is a combination of conventional systems with online. More use of online learning systems during the Pandemic (80%) compared to traditional face-to-face learning systems. The merger of the two systems includes the incorporation of learning resources as well (learning modules, textbooks, and journals), the implementation of learning (online discussions, watching videos, and accessing supporting resources, and the incorporation of a learning evaluation system, including standardized assessment through quizzing, midterm exams, and final exams. (2) the results of the implementation of blended learning in Ulumul Qur'an courses are illustrated from five main aspects, namely (a) increased utilization of various sources, (b) increased active participation, (c) increased ability to construct knowledge, (d) activation of feedback, and (e) improvement of academic achievement

Elucidating the Genetic Basis of Neurological Disorders in Pakistani Population

Human brain development is a complex process involving many cellular pathways. Pathogenic mutations in genes controlling as a whole or in parts, any of these cellular processes result in neurological disorders. It is basically due to defective signaling function in central or peripheral nervous system. The clinical features of such disorders are extremely diverse and overlapping, with even greater genetic heterogeneity. They may either be simple, having Mendelian inheritance or they may be complex. Genetic factors play very important role both in simple and complex neurological diseases. The consequences of such diseases are usually devastating both for affected individuals, their families and society, mainly by affecting the qualities which make human special as person; the character, memory, cognition, communication and skilled movements. In the present study, 11 consanguineous Pakistani families having neurological disorders of Mendelian inheritance were investigated using next generation sequencing (NGS) technologies. Rare and disease causing variants mostly occur in coding part of genome. Whole exome sequencing (WES) was used as a method of choice in the current study because of the heterogeneous nature of neurological disorders both clinically and genetically. Variants obtained from WES were prioritized based on their inheritance pattern, disease association, functional relevance and pathogenicity score as predicted by different bioinformatics tools such as Mutation Taster and PolyPhen-2. Segregation of all the variants were confirmed using Sanger sequencing. Ten novel and one already reported mutation were identified in this study. At present there are no effective treatment strategies available for most of these diseases. Therefore, identification of gene/s and pathogenic variant/s in these diseases will help understand underlying molecular mechanisms better, and lead to improved strategies both for genetic counseling and potential therapeutics
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