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یک طرفہ محبت کا قصہ جو لکھا ہوتا
یک طرفہ محبت کا قصہ جو لکھا ہوتا
دیوانہ ہے، چھوڑو نا! بس تم نے کہا ہوتا
تم یاد کرو بیٹھے اب قیس میاں ہی کو
میں ایک صدا کرتی دشت آن کھڑا ہوتا
پتھرائی ہوئی آنکھیں رستہ ہوئی جاتی ہیں
اک بار پلٹ آتے، وعدہ تو وفا ہوتا
بے مول ہوا ہے اب، انمول کبھی تھا یہ
دل ہم کو دیا ہوتا، احسان کیا ہوتا
قاصر تھی زباں تیری جاتے ہوئے کہنے سے
آنکھوں سے کہا ہوتا، اس دل نے سنا ہوتا
اک اور غزل کہہ دوں حسرتؔ کی زمیں ہے خوب
احوال سنانے کو جو تم نے کہا ہوتا
پھر درد دوا ہوتا اور چاند نگر مسکن
پہلو میں فضاؔ کے گر وہ شخص کھڑا ہوتا
Cytotoxic Assessment of Quinoline Based Derivatives on Liver Cancer Cell Line Quinoline compounds and their Cytotoxicity
Current scenario of newer diseases with multiple causes has drawn the attention of the researchers in the field of therapeutics and they are now inclined to identify molecules effective for targeted therapy. Objective: Quinoline (1-azanaphthalene); belongs to heterocyclic aromatic nitrogen compound. Some quinoline-based derivatives are also known for their anti-tumor activity. The study was planned to evaluate the cytotoxic potential of quinoline derivatives. Methods: Berberine; a quinoline compound was made part of study to make structural analogs which were docked against potential target proteins. Cytotoxic profiling of all derivatives was done using MTT cytotoxicity assay. Results: The pharmacoinformatic and structure activity relationship studies of analogs were done. The cytotoxic profiles were elucidated by comparing viability rates of analogs treated hepatic cancerous cell line with untreated hepatic cells and untreated mesenchymal stem cells as standards. Marked cytotoxicity was seen in all molecules at low doses than reported in past studies with relevance to parent compound. Conclusions: The results will be further confirmed through various other cell culture assays targeting different marker proteins, pharmacoinformatics tools and structure activity relationship studiesThe Dynamics of Pakistan-China Strategic Relations: Challenges and Prospects in the Post 9/11 Era.
The dynamics of Pakistan-China strategic relations are increasingly shaped by the global power play in Asia Pacific region which is emerging as a new pivot strategically and economically for the whole globe. China has remained most significant strategic ally of Pakistan and its relations have largely been driven by its strategic necessity to continue balance of power in region. The nuclearisation of India in South Asia and its strategic partnership with US and desire to play a soft balancer‘s role in Asia Pacific has accentuated Pakistan-China strategic relationship. Both neighboring states China and Pakistan has had expressed commonality of interests at bilateral, regional and international levels. At the bilateral level China perceives Pakistan as a viable corridor for energy resources from oil and gas rich Middle East in her regional as well as in global perspective. For Pakistan its strategic partnership with China has played very important role in country‘s security against her arch rival, the hegemonic India. The recently launched China-Pakistan Economic Corridor (CPEC) would not only strengthen economic partnership but also create mutual strategic interdependence between the two neighboring states. Geopolitical scenario is getting more multifaceted with the passage of time with impending challenges and enormous opportunities. The study argues that the shifting structures of security in Asian Supercomplexare increasingly reinforcing the dynamics of Pakistan-China strategic relations in the twenty first century. Using the main framework of Regional Security Complex theory it examines the growing interplay of Asian Supercomplex with the South Asian Regional Security Complex which is marked by increased US-China strategic competition in Indo-Pacific region and China‘s Malacca dilemma as well as growing Indo-US strategic partnership in the region. In search of viable alternate energy routes, China has turned to Pakistan and initiated CPEC which will allow Beijing to use Gwadar port for transportation of Middle Eastern oil to Xinjiang through the pipeline. This has created a new set of strategic complex interdependence between Pakistan and China which is likely to sustain their strategic relationship in future.Journals by Discipline
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