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Foreword Two

Foreword Two

Brother Dr. Badr Hashemi has devoted care and attention to the tone and approach of the Translation and Paraphrasing of The Qur’an which is non-sectarian, true to the spiritual intent of Allah-consciousness, sincere toward leading to piety and righteousness.

The style of presenting the Translation, which proceeds smoothly in strict conformity with the Sacred Arabic Text and Paraphrasing (in italics) is persuasive that is inviting both for Muslim readers and others.

This is the most profound scholarly work of Brother Badr Hashemi. His monumental translation and annotation serve as a matchless aid to understanding the Holy Book of Islam and provides in itself a complete education in the faith. If one is new to the Holy Qur’an, I hope this book will provide a balanced view of the heart of the Qur‘an. If one is already a student of the Holy Qur’an, I hope this will perhaps awaken a new appreciation for the universal spiritual wisdom of the Book.

Reading a good translation such as this one can help us not only gain wisdom but also articulate this wisdom for others. I trust it would equally help in refining and fine tuning what everyone knows about the Qur’an, Islam, and Muslims.

May Allah accept this service to His Book, and enable his readers - especially students in colleges and universities - to make the best use of this valuable contribution to the Study of
The Qur’an.

Prof. Dr. Hafiz Abdur Raheem.
Dean
Faculty of Islamic Studies and Languages, Bahauddin Zakaria University, Multan, Pakistan.

الجملة المعترضة فى القرآن الكريم: دراسة بلاغية

This study aims to prove that the Parenthetical Sentences in the Quran are not a way to improve the beauty of literature, but if they appeared in a convenient location they became the requirements of the text. The main findings of this study include the parenthetical sentences in the Holy Quran characterized by specific semantics which is known by the context of Ayat and not only because of assertion, embellishment or clarification. These sentences would inspire the attention from the reciter of Quran to think of the underlying meaning. The parenthetical sentences in Quran cannot be nullified as this will divert the true meaning of Ayat e Kareemas.

Formulation Development and In-Vivo Performance of Pharmaceutical Cocrystals

Formulation Development and in-vivo Performance of Pharmaceutical Cocrystals The use of soluble cocrystal for delivering drugs with low solubility, although a potentially effective approach, often suffer from the problem of rapid disproportionation during dissolution, which negates the solubility advantages offered by the cocrystal. This necessitates their robust stabilization in order for successful use in a tablet dosage form. The cocrystal between carbamezepine and succinic acid (CBZ-SUC) exhibits a higher aqueous solubility than its dihydrate, which is the stable form in water. Using this model system, I demonstrate an efficient and material-sparing tablet formulation screening approach enabled by intrinsic dissolution rate measurements. Three tablet formulations capable of stabilizing the cocrystals both under accelerated condition of 40oC and 75% RH and during dissolution were developed using three different polymers, Soluplus® (F1), Kollidon VA/64 (F2) and Hydroxypropyl methyl cellulose Acetate sucinate (F3). When compared to a marketed product, Epitol® 200 mg tablets (F0), drug release after 60 min from formulations F1 (~82%), F2 (~95%) and F3 (~95%) was all higher than that from Epitol® (79%) in a modified simulated intestinal fluid. Studies in albino rabbits showed correspondingly better bioavailability of F1 – F3 than Epitol® tablets. All the three experimental formulations gave statistically significant improvements in AUC0-72 of CBZ than Epitol tablets by applying ANOVA followed by Tukey’s post hoc test (*P˂0.05 for F0-F1, ***P˂0.05 F0-F2, ***P˂0.05 F0-F3). Among the three formulations, F2 tablet formation was the best based on both in-vitro and in-vivo evaluations. Towards the second formulation approach, I first used common polymers to study the supersaturation of carbamezepine-succinic acid (CBZ-SUC) cocrystal at different conditions. In-situ Raman spectroscopy was used to monitor the solid phase during dissolution studies. The solid phase at the end of each experiment was characterized by FTIR and powder X-Ray diffractometry. In-vivo study was performed on selected xi suspension formulations. In absence of polymers, no dissolution advantage was attained by cocrystals due to rapid crystallization of CBZ dihydrate. At room temperature Polyvinyl pyrrolidone (PVP) at concentration of 2% w/v did not stabilize the supersaturated solution, whereas polymer concentration of 0.025% w/v hydroxypropyl methyl cellulose acetate succinate (HPMCAS) stabilized the cocrystal and enhanced the solubility of CBZ in buffer solution at pH 6.8 by 3.2folds to that of stable dihydrate form. A formulation of CBZ-SUC cocrystal containing HPMCAS as a crystallization inhibitor and soluplus® as solubilizer, superior in-vitro dissolution performance was achieved compare to pure CBZ having similar composition at 37±1Ċ. Pharmacokinetic studies in rabbits showed that one of the formulations F7-X (1% w/v cocrystal, 1% w/v HPMCAS and 2% w/v soluplus®), caused around 6folds enhancement in AUC0-72 (***P˂ 0.05), and also led to a much higher Cmax of 4.73 μg/mL than 1.07 μg/mL Cmax of ‘neat’ cocrystal given orally. Also, the F7-X outperformed a reference formulation of CBZ by {1.37folds AUC0-72 of cocrystal formulation (***P˂ 0.05) and Cmax of 3.9 μg/mL} with similar composition to F7-X.
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