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آرزو

آرزو
اے نقطہ راز کے واقف۔۔۔!
اے نقطہ راز کے واقف۔۔۔!
پہچان کے درویش۔۔۔و مِن الاصحاب عشق کا دعوی کرنے والے!
اے آشناء مستی کے روبرو۔۔۔!
افاعیل میں زحافات کی تقطیع کے اصلاحی علائم کو!
نظم میںمشخص کرنے والے۔۔۔!
ستیہ پال آنند، امجد اسلام امجد اور علی محمد فرشی مجھ سے بولتے نہیں
خالد سجاد ، اظہر عباس اور نعیم گیلانی تھکے ہوئے ہیں
ماجد مشتاق، افتخار شفیع اور شبیر بٹ سوئے ہوئے ہیں
ہوا شبنمی خوشبو کے ہم رکاب چل رہی ہے
چاندنی خشک کوزوں میں اترتے ہوئے!
محبت پہ درود اور چاہت پر سلام پڑھ رہی ہے
اب تم ہی آجاؤ نا۔۔۔!
ہم ترجیحی تدوین۔۔۔اختصار ترکیب پہ نہ سہی۔۔۔!
چلو نثری نظم پہ ہی مناظرہ کرتے ہیں

مقاصد شریعت اور حقوق کی ادائیگی کا باہمی ربط: ایک تحقیقی جائزہ

Allah guided His men through great Prophets and messengers who, through their active economic, religious and politico-economic lives, taught the people how to lead a life. As the people have to come across all these fields of life, therefore, performing rights and duties is essential for a peaceful society. The accomplishment of Sharia objectives depends on the performance of rights and duties. If there is some breach in these rights and duties, the Sharia objectives are lost. If we ponder over the decrees of Allah, it becomes clear that the accomplishment of the decrees itself is the permanence of rights and duties. In this research paper, the rights of the Creator on His men and the rights of men on their Creator, Similarly, the rights of men among themselves and their performance, and the rights of animals and how they can be performed have been described and these Sharia objectives rights are closely related to each other.

Neuropharmacological Studies in Rat Models on Morphine and Nalbuphine Induced Addiction, Anti-Nociception and Serotonin-1A Receptor Expression for Improving Therapeutics in Pain

Morphine and other opioids are the most effective prescription medications for the treatment of pain. Associated addiction and hyperalgesia, however, limits the clinical utility of these drugs. The present study aimed to determine the potential effectiveness of buspirone, a partial agonist at 5-hydroxytryptamine (5-HT, serotonin)-1A receptor in reducing morphine-induced addiction and hyperalgesia. We found that co-administration of buspirone with morphine inhibited reinforcing as well as hyperalgesic effects of morphine. Tolerance in motor depressant effects of morphine was also reversed. Effects of morphine on dopamine and serotonin metabolism in nucleus accumbens and caudate were also reversed by buspirone co-administration. Reinforcing, analgesic, and motor effects of nalbuphine, another opioid drug, were also monitored. Both low and high doses of nalbuphine produced reinforcing effects. High but not low doses produced sensitization. Moderate doses of nalbuphine did not produce reinforcement or sensitization like effects. Moderate doses of nalbuphine produced greater pain killing effects than smaller or higher doses. We also determined the effects of repeated administration of buspirone on memory, pain perception, and 5-HT1A receptor expression in brain regions associated with addiction and memory. Administration of buspirone at 1 mg/kg but not at 0.3 mg/kg or 0.1 mg/kg produced significant analgesic effects. Repeated administration of buspirone at doses of 0.1 and 1 mg/kg but not at 0.3 mg/kg produced hyperalgesia. Low buspirone dosage (0.1 mg/kg) improved, while higher dosages (0.3 and 1 mg/kg) impaired performance in Morris water maze. This was associated with the down-regulation of serotonin-1A receptors in the prefrontal cortex and hippocampus. The findings show an important role of 5-HT1A receptor in morphine abuse and hyperalgesia. It is suggested that clinicians should consider buspirone as adjunctive therapy with morphine to prevent its abuse during the treatment. Because higher but not lower doses of buspirone were found to impair cognition; lower doses may be preferably used to improve therapeutics in chronic pain.
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