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پہلی گل

پہلی گل
پاکستان ایئر فورس دی ملازمت دے دور ان رسالپور اکیڈمی دے وچ جس ویلے میں ایم۔اے پنجابی کیتا تے دل وچ ہک کرلاٹ پے گئی۔کیوں کہ پنجابی ادب بندے نوں ورثے وچ ملیا سی۔والد صاحب حافظ قرآن تے درویش منش آدمی سن۔تے پنجابی دیاں کتاباں ،ہیر وارث شاہ،سسی پنوں،یوسف زلیخا،مولوی غلام رسول،کافیاں بُلھے شاہ،کافیاں شاہ حسین،سی حرفی سلطان باہو تے بوٹے گجراتی دیاں سی حرفیاں،تے دائم اقبال دائم دی کتاب سیف الملوک وغیرہ پہلے ہی گھر وچ مو جود سن۔ایس واسطے زیادہ تر سی حرفیاںتے بارہ ماہ ۱۹۹۴ئ،۱۹۹۵ء وچ ای لکھے گئے۔
وقت گزر دار ہیا تے ۲۰۱۸ء وچ بندے نیں ایم۔فل اردو کیتا تے اردو ،پنجابی وچ لکھن دا شوق پیدا ہویا۔بقول وارث شاہ:
’’بجھی عشق دی اگ نوں وا لگی،سماں آیا ای شوق جگاونے دا ‘‘
پنجابی غزلاں زیادہ تر ۲۰۱۸ تے ۲۰۱۹ وچ لکھیا ں گئیاں۔کتاب دا ناں’’دکھاں دی پنڈ ‘‘میرے اپنے ذہن دی پیداوار اے۔دنیاں دُکھّاں تے مصیبتاں دا گھر اے۔دنیا تے بھانویں کوئی جیڈا وی سکھی ہووے ،کوئی نہ کوئیدکھ ہر اک نوں ضرور ہوندا اے۔سیانے آکھدے نیں’’دکھاں توں بعد ای سکھ ملدے نیں‘‘۔جے دھپ ہے تے چھاں ہے،جے رات ہے تے دن ہے،جے ہنیرا ہے تے چانن ہے۔پھل بڑے نازک تے خوشبوواں دیون والے ہوندے نیں پر کنڈیاں توں خالی نہیں ۔ایس واسطے سکھاں دا صواد وی دکھاں توں بعد ہی اوندا اے۔
’’یار میرا جے دکھ وچ راضی، میں سکھ نوں چلھے پاواں‘‘
جے بندے نوں کوئی وی دکھ نہ ہووے تے وقتِ نزع تاں گیا ہی کدائیں نہیں۔
ساڈے با بے آدم نوں رب نے جنت وچوں کڈھ کے تے زمین تے چا سٹیا۔گویا جنت وچوں نکل کے ہک قسم دے دوزخ وچ آ گئے،تے نال ہی’’دکھاں دی پنڈ ‘‘سر تے آ گئی۔اﷲ پاک نے اپنے ساریاں پیاریاں پیغمبراں نوں دکھ دے کے آزمایا۔وصل دیاں لذتاں وی ہجر فراق...

مناهج المؤرخين المعاصرين في كتابة السيرة النبوية: شلبي وشاكر أنموذجا

This paper encompassed the methods of contemporary historians in presenting the Prophet's biography: Shalabī and Shākir as a model. The purpose of this research was a comparative study of the methods of two different contemporary writers in the field of biography. The method used for the research was comparative. This fact was established that there are very few contemporary historians who contributed in writing of the Prophet's biography, but although these two important historians were diligent researchers with good works and successful writings, but much that they have benefited from history needs and objected even settled facts like some of the correct aḥādīth and some important events that took place in the in reference no is there as (صلى الله عليه وسلم) Muhammad Prophet Great the of biography the books to the sources relied on in the historical narratives, nor in the narration of the biography. There are many shortcomings in the two books which are in the most important Islamic arts, especially in the Encyclopedia of Dr. Shākir, and special research and books should be devoted to the answers to the silence of such shortcomings, and there is a strong need to compose valuable books in response to the shortcomings of such sporadic encyclopedias. Special books in such art must be devoted to the important Islamic arts, and do not include a variety of subjects on general history. (صلى الله عليه وسلم) biography Muhammad s'Prophet the of art the inc

Modelling of Tlr4 and Jak/Stat Signalling Pathways and Protein-Protein Interaction Studies to Examine the Pathophysiology of Sepsis

In this thesis, the medical condition of sepsis is considered at molecular level (signalling pathways) using computational systems-level approaches in order to get insights into the mechanism of disease progression. Sepsis is the pathological condition provoked due to the presence of bacterial endotoxin in the bloodstream. Subsequently Toll like receptors (TLR)4 and JAK/STAT signalling pathways attempt to reduce the pathogen burden by inducing pro- and anti-inflammatory innate immune responses. However, in some instances, an overwhelmed immune system could not properly regulate the balance between infection and inflammation that may ultimately lead to organ damage and consequently to death. In recent years, there has been an increasing amount of literature on the pattern of pro- and anti-inflammatory response elicited during sepsis, though; there has been a little agreement on the roles of pro- and antiinflammatory cytokines (AiCyts) in sepsis. This study mainly aims to address the controversy behind roles of pro- and anti-inflammatory cytokines in sepsis by modelling the signalling pathway of TLR4 and one of the connected signalling cascades of JAK/STAT using qualitative modelling approach introduced by René Thomas’. The possible system dynamics of TLR4-JAK/STAT signalling pathways are produced for two medical conditions i.e. non-sepsis (type of infections that generally do not cause sepsis) and sepsis along with perturbations in these two cases. As a result, recurrent induction and inactivation of pro-inflammatory cytokines is found as the basic feature associated with sepsis. Besides AiCyts, IFN-β and SOCS-1 are found to mediate down-regulation of pro-inflammatory cytokines at different stages of signalling which cause variation of pro-inflammatory cytokines levels. It is observed that intervention in IFN-β mediated down-regulation of pro-inflammatory cytokines at earlier stages of system dynamics, while intervening the SOCS-1 mediated down-regulation of proinflammatory cytokines at later stages ensures hyper-inflammatory condition. On the other hand, interventions in TLR4, NFκB (transcription factor involved in the TLR4 1 Abstract signalling pathway) and JAK/STAT signalling are good choices for supporting the anti-inflammatory immune responses. Thus only possible protein-protein interactions involved in the initial downstream interactions of TLR4 signalling are studied in order to predict a more appropriate target in these interactions. Previous studies indicated that MyD88 adaptor-like protein (MAL) is an endogenous adaptor protein recognized as an important protein involved in the induction of TLR4 mediated downstream signalling pathway. Moreover, it has also been demonstrated that BTK and PKCδ phosphorylate MAL (positions Tyr86 and Tyr106) which ultimately activates MAL. Thus the modelling of PKCδ and protein-protein interactions of both BTK and PKCδ with MAL is performed in order to explore their competitive interaction. Molecular docking and physicochemical analysis reveals that PKCδ may phosphorylate only Tyr106 of MAL, while BTK may phosphorylate MAL at both positions. Interestingly, the charge and hydrophobicity at interfaces of PKCδ and BTK are found different in nature yet well-compatible with the individual positions of Tyr86 and Tyr106 of MAL. The most prominent findings emerged from this analysis is that position Tyr86 of MAL may explicitly be phosphorylated by BTK, while position Tyr106 of MAL may be phosphorylated by the competing interest of both PKCδ and BTK. In conclusion, this thesis will enhance our understanding about the signalling and protein-protein interactions involved in sepsis which will contribute to the development of drugs and vaccines against the medical condition of sepsis.
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