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حکیم حبیب الرحمن

حکیم حبیب الرحمن مرحوم ڈھاکہ
ڈھاکہ کے متعدد دوستوں کے خطوط سے یہ معلوم کرکے بڑا افسوس ہوا کہ بنگال کے جادو نگار ادیب اور نادرۂ روزگار طبیب شفاء الملک حکیم حبیب الرحمن نے یکم ربیع الثانی ۱۳۶۶؁ھ کی شب میں ضغطہ دم (بلڈ پریشر) کی بیماری میں سنہ قمری سے اڑسٹھ اور شمسی سے چھیاسٹھ برس کی عمر میں دفعتہ وفات پائی، مولانا ظفر احمد صاحب عثمانی تھانوی اپنے والا نامہ میں لکھتے ہیں:
’’آپ کو وفیات لکھنے میں ملکہ ہے ایک اور وفات نامہ معارف میں لکھ دیجیے، آپ کے اور میرے مخلص دوست حکیم حبیب الرحمن صاحب کا یکم ربیع الثانی ۱۳۶۶؁ھ مطابق ۲۳؍ فروری ۱۹۴۷؁ء کی شب میں دفعتہ بلڈ پریشر بڑھ جانے سے انتقال ہوگیا، اناﷲ۔
مرحوم حضرت حکیم الامت تھانویؒ کے ابتدائی صرف ونحو کے شاگرد اور بڑے عاشق تھے، علامہ شبلی کے دوستوں میں تھے، مسلم لیگ کی جب بنیاد ۱۹۰۶؁ء میں ڈھاکہ میں رکھی گئی اور نواب سر سلیم اﷲ خان اس کے صدر ہوئے تو مرحوم جوائنٹ سکریڑی ہوئے تھے، علم طب حکیم عبدالمجید خان صاحب سے حاصل کیا، اور اس میں کمال کا درجہ پایا، بنگال میں اس وقت ان کے درجہ کا کوئی طبیب نہیں سنا گیا، ڈھاکہ میں طبیہ کالج قائم کیا، اور بڑی ہمت سے اس کو چلانے سے گورنمنٹ نے شفاء الملک کا خطاب دیا، جس کو ( لیگ کی تحریک کی بنا پر) ستمبر میں واپس کردیا‘‘۔
ان کے اس کالج سے بہت سے اطبا پیدا ہوئے اور اب بھی سلسلہ درس جاری ہے اور خدا کرے برابر جاری رہے۔
مولانا شبلی مرحوم مسلم ایجوکیشنل کانفرنس کے سالانہ اجلاس کے سلسلہ میں ۱۹۰۶؁ء میں ڈھاکہ تشریف لے گئے تھے، وہاں سے دو دوستوں کے نام ہم لوگوں کے لیے تحفہ میں اپنے ساتھ لائے، ایک کا نام مرزا فقیر محمد صاحب...

A Welcome Message from The Editor

It is with profound pleasure that we write this editorial to welcome you to the new journal, “Pakistan Biomedical Journal” (PBMJ), an interdisciplinary international journal. PBMJ has successfully completed its first volume and now its the second volume. We greatly appreciate the response of scientists who have contributed previously and are still contributing to this new journal. The subject of the journal is interesting and we try to address the health related concerns of public and improve the understandingof scientific phenomenons by researchers. Research discoveries are happening at a fast pace, in all the fields and PBMJ provides an ideal forum for exchange of scientific knowledge in terms of full length papers, surveys, reviews, case studies, letters to editor and systematic analysis. PBMJ is committed to publishing all manuscripts receiving a high recommendation from reviewers. The intention of PBMJ is to create space for generation of new knowledge, debate, collaborations among national and international scientists. Our vision is to promote research that will be helpful for knowledge sharing, new discoveries, development of critical thinking among the upcoming scholars, guidance for policy makers, awareness among the concerned community and ultimately benefitting the general population in improving health and fitness at large. It is a matter of pride for us to haveexcellent editorial board members from renowned institutes. We aim to have the best standards of quality of the published manuscripts. With every issue, we are continuously trying to improve the standards. We look forward for more exciting researches and scientific studies from all over the world. We would like to extend a very warm welcome to the readers of PBMJ and hope you will join us as authors, reviewers and editors in future.

Solid Lipid Nanoparticles for Thermoresponsive Drug Delivery: Fabrication and Evaluation

Thermoresponsive drug delivery systems (DDS) are designed for the controlled and targeted release of therapeutic payload by exploiting the hyperthermic temperature (>39°C), which may be applied by some external means or an encountered symptom in inflammatory diseases such as cancer, arthritis etc. However, available thermoresponsive DDS, including liposomes, have complex method of preparation involving toxic solvents and reagents. Recently, we have shown for the first time that melting point of solid lipid nanoparticles (SLN) can be optimized for thermoresponsive drug release by tuning their melting point (MP). The objective of this study was to provide some strong evidence in support of hypothesis that thermoresponsive solid lipid nanoparticles (TSLN) undergo solid-liquid phase transition at their melting point (>39ºC) leading to faster drug release. Thermoresponsive lipid mixtures (TLM) were prepared by mixing solid (lauric, myristic, palmitic and stearic acid) and liquid (oleic and linoleic acid) natural fatty acids in different ratios (0.1:1 to 1:2) and melting point was measured by differential scanning calorimetry (DSC). A graph was plotted between liquid content in TLM and the MP, and TLM that would melt at 39°C were identified by using straight line equation of the graph. The solidliquid phase transition was assessed by determination of temperature dependent change in viscosity (low at 39°C) and light transmission (higher at 39°C) that are characteristic of liquids. TSLN containing a chemotherapeutic drug, either hydrophilic 5-fluorouracil (5-FU) or lipophilic paclitaxel, were synthesized by hot melt encapsulation method. It should be noted that the TLM and the TSLN were made by physical interaction of materials and no chemical reaction was needed. The TSLN showed desirable spherical shape (TEM), size (100-300 nm), physicochemical stability (FTIR analysis), high yield (>85%) and encapsulation efficinecy (5-FU >40% and paclitaxel >90%). In 5-FU loaded TSLN, drug release studies were first performed by USP type II dissolution apparatus in PBS (7.4) at 37°C and 39°C. A sustained release pattern was observed at 37°C and 22-34% 5-FU was released in 5 hrs. On the other hand, >90% drug was released at 39°C suggesting that the SLN show thermoresponsive drug release in agreement with our hypothesis. Drug release from SLN at 39°C was similar to model oleic acid and linoleic acid nanoemulsions which further supports our hypothesis. Next, a quick and real-time differential pulse voltammetry (DPV) based electrochemical chemical detection method was developed using a graphite electrode to detect change in current with 5-FU concentration while increasing voltage was applied on reference and counter electrodes. This method also showed that sustained release pattern of 5-FU at 37°C was converted to an immediate drug release when heated to 39°C, thus, confirming the thermoresponsive drug release. In case of paclitaxel loaded TSLN, drug release was minimum at 37°C and 70-100% drug release achieved after 60 hrs. On the other hand, whole drug was released in 4-7 hours at 39°C. This 15-20 time higher drug release at hyperthermic conditions confirmed the thermoresponsive drug release from the TSLN. Blank SLN were found to be biocompatible with human gingival fibroblast cells (PCS- 201-108) although and breast cancer cells (MDA-MB-231). However, 5-FU loaded SLN showed some cytotoxicity after 24 hours which was due to the release of drug. 5-FU loaded SLN showed thermoresponsive cytotoxicity to breast cancer cells (MDA-MB-231) as cytotoxicity was higher at 39°C (22-28%) compared to 37°C (<10%) within 1 hour. Similarly, paclitaxel loaded TSLN showed higher cytotoxicity to glioblastoma cells at 39°C (31% cell viability after one hour) compared to 37°C (18% cell viability). The higher cytotoxicity at 39°C was due to the higher drug release. Finally, the TSLN were evaluated for brain targeting across blood brain barrier (BBB) and an in vitro BBB model was used consisting astrocytes (CRL-2541) and endothelial cells (b.End3). The BBB model was optimized at 39°C for 1 hour duration due to retention of semipermeable nature and lack of paclitaxel and heat related toxicity. The TSLN showed higher permeability across BBB at 39°C which may be attributed to the deformable liquid state that squeezes through the tight junctions of BBB without any damaging effects. In conclusion, the novel TSLN reported in this thesis may serve as safe and effective platform of thermoresponsive targeting of cancer.
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