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عارف عباسی

عارفؔ عباسی
عارف عباسی بھی اﷲ کو پیارے ہوگئے، وہ اس دور کے ممتاز غزل گو اور جگر کے طرز کے کامیاب مقلد تھے، انہوں نے اپنی ظاہری وضع و قطع بھی انہی کی جیسی بنالی تھی، ان کا مکان اعظم گڑھ سے متصل ضلع ملبا میں تھا اس لئے اعظم گڑھ میں اُن کے پرانے تعلقات تھے اور یہاں برابر اُن کی آمدورفت رہتی تھی پہلے جب اعظم گڑھ آنا ہوتا تھا تو دارالمصنفین ضرور آتے تھے، اور اپنے تازہ کلام سے محظوظ کرتے تھے، مگر ادھر کچھ دنوں سے اس وضعداری میں فرق آگیا تھا، عرصہ تک اُن کی غزلیں معارف میں چھپتی رہیں، اُن کے تعزل میں بڑی لطافت و پاکیزگی تھی ابتدا میں راجہ صاحب نانپارہ کے لڑکوں کے اتالیق رہے تھے، اس لئے درباری آداب اور علم مجلس کے بڑے ماہر تھے، اُن کی عمر ساٹھ باسٹھ سال کی رہی ہوگی، ادھر کچھ دنوں سے کچھ قلبی شکایت ہوگئی تھی، اسی نے مرض الموت کی شکل اختیار کرلی، اﷲ تعالیٰ ان کی مغفرت فرمائے۔ (شاہ معین الدین ندوی،نومبر ۱۹۷۱ء)

KRISIS DISIPLIN PENDIDIKAN ISLAM: ANTI PLURALISME

This article discusses the problem of Islamic education from a theological and sociological point of view. The emergence of normative and verbalist Islamic education curriculum distorts the universality of Islam. Islam that is contextual in space and time, always in contact with sociological aspects, should be understood as something that can change its partiality dynamics continuously, even though there is a universal thing that is maintained as a normative belief. On the other hand, the failure of education to produce educational output that is dignified and virtuous has caused some people to distrust the world of education in developing the character and ethics of children. The vote of disbelief is getting stronger with the emergence of the National curriculum model which gives a greater portion of general subjects than religious subjects. This paper is a criticism of the development of the world of education in Indonesia, with the hope that education stakeholders make changes to the education system and the applicable curriculum.

Therapeutic Effects and Safety Profile of Atorvastatin on Psoriasis Severity Associated With Cardiovascular Risk

Several studies occurs on anti-hyperlipidemic drug Atorvastatin and its pleotropic effects. However its relationship with Psoriasis and association of cardiovascular risk in comparison of standard therapy with large sample size has not been studied in Pakistan. Topical Betamethasone is the first line treatment in the management of all grades of Psoriasis as a monotherapy and in combination therapy. Beyond lipid lowering mechanism Atorvastatin have pleiotropic effect through direct inhibition of small GTPase protein (Rho, Rac, Ras and Rab). These protein control multiple signaling pathways involve in pathogenesis of immuno-inflammatory diseases like Psoriasis. Statin modulates the altered expression of these prenylated proteins. Psoriasis is important disease for researcher because it serves as a model disease to study the basic principle of immune mediated inflammation that is the reason by which in clinical trial it acts as a model for new research studies. Psoriasis is associated with other co-morbidities, the most important is cardiovascular risk. OBJECTIVE: Present study demonstrates that Atorvastatin has dual action on severity of psoriasis and cardiovascular risk (CVR). METHODS: This was an interventional study conducted in Pharmacology Department of BMSI, JPMC with the collaboration of Pathology Department, BMSI, JPMC and Dermatology Department of JPMC. This research project consist of two phases one was the preclinical conducted on ninety adult Wistar Albino rats divided into three groups, Group A (Control), Group B (Doxorubicin induced toxicity) and Group C (Atorvastatin pretreated). Other was the clinical study on mild to moderate xxvi plaque type psoriatic patients. 225 psoriatic patients enrolled in this study those who fulfilled the inclusion and exclusion criteria. The inclusion criteria were, both male and female age ranging from 25-65 years, PASI score <12, hs C-RP ≥ 3. These patients further divided into three groups. Group A prescribed tab. Atorvastatin 80mg for first three month followed by 40mg for next three months. Group B prescribed Placebo and topical Betamethasone valerate 0.1% twice daily for 3 months and once a day for the next 3 months (three weeks apply than one week interval and for sensitive area 50% betamethasone in soft paraffin). Group C prescribed tab. Atorvastatin 40mg for the first three months followed by 20 mg for next three months plus topical Betamethasone valerate 0.1% once daily for 6 months (three weeks apply than one week interval and for sensitive area 50% betamethasone in soft paraffin). The efficacy and safety profile of drug assists preclinically by biopsy of rats myocardium and clinically by PASI, hsCRP, DLQI, Lipid Profile, LFTs and CPK.
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