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پروفیسر حا فظ محمود خان شیرانی

پروفیسر حافظ محمود خان شیرانی مرحوم
ہم کو ابھی تک اپنے ملک کے علماء اور محققین کی پوری قدر نہیں ہوئی، کیسے افسوس کی بات ہے کہ ہماری قوم اور ملک کے ایک نامور محقق پروفیسر حافظ محمود خان شیرانی کا انتقال ۱۶؍ فروری ۱۹۴۶؁ء کو ٹونک میں ہوگیا، اور ہم میں سے بہتوں کو اس کی خبر نہیں ہوئی۔
شیرانی مرحوم کا وطن ٹونک تھا، شیرانی پٹھان تھے، اور ان کو اپنے پٹھان ہونے پر فخر تھا، ٹونک ہمیشہ سے علماء اور محققین کا مقام رہا، وہاں کا نادر کتب خانہ اکثر محققوں کو اپنی طرف کھینچ کر لے جایا کرتا ہے، اور شیرانی کا تو وہ وطن ہی تھا، شیرانی صاحب کی انگریزی کی استعداد پوری تھی، فارسی کی تعلیم متوسط اور عربی کی معمولی مگر ان میں تحقیق و تلاش کا مادہ فطرۃً تھا، تاریخ اور خصوصاً تاریخ ادب سے ان کو بے حد شغف تھا، تاریخ کے ذوق سے ان کو کتبوں اور سکون کا شوق تھا، اسی شوق سے وہ لکھنؤ بھی آتے تھے، اور چونکہ ہمارے مدرسہ دارالعلوم ندوۃ العلماء کے درس اول و شیخ الحدیث مولانا حیدر حسن خان صاحب مرحوم بھی ٹونکی تھے، اس تعلق سے وہ کبھی کبھی ہمارے مدرسہ میں بھی ٹھہرتے تھے اور اسی واسطہ سے میری ان کی ملاقات ہوئی، اور اس کے بعد جب وہ لاہور تھے، تو کئی بار ملنا ہوا۔
مرحوم کا سال پیدایش ۱۲۹۸؁ھ ہے، عمر قریباً سرسٹھ برس تھی ۱۹۰۴؁ء میں اسکول کی تعلیم چھوڑ کر بیرسٹری کے لیے لندن گئے، جہاں سے والد کی وفات پر ۱۹۰۶؁ء میں واپس آئے، پھر فوراً واپس گئے، اور ۱۹۱۴؁ء میں واپس آئے، بیرسٹرتو نہیں ہوئے، مگر قلمی کتابوں کا شوق پید اہوگیا، پیرس کے قومی کتب خانہ میں تین ماہ مصروف رہے، اور وہیں بعض فرانسیسی اہل علم کے ساتھ مل کر...

Phase-dependent expression profiling and quantification of several growth factors in liver regeneration after partial hepatectomy

Growth factors are the potential operational members which control different phases of liver regeneration. Different growth factors have expression regulation in the whole process relating to different phases of liver regeneration. Objective: To assess the expression regulation of different growth factors and cytokines involved in liver regeneration in a phase-dependent manner. Methods: Blood and liver samples were collected and analyzed on 1st, 3rd, 5th, 7th and 14th postoperative days after 50% Partia hepatectomy (PHx). Results: Steady increase of liver regeneration rate was recorded from 90.8% (1st day) to 97.9% (7th day). Liver function tests further confirmed the steady liver recovery in PHx mice. Several growth factors such as HGF and VEGF exhibited an up-regulation till 5th day and later gradual decrease till 14th day compared to control mice. Albumin, CK18 and CK19 showed sequential expression increase from 1st to 14th day compared to AFP and HNF-4α upregulated until 5th and 1st day, respectively. Quantification of these growth factors further confirm our results. Conclusions: Conclusively, these results highlight a phase-dependent regulation and role of growth factors in liver regeneration and recovery

Performance of Canola under Summer Crops Green Manuring Management Scenarios and Varying Nitrogen Levels

The improved varieties of field crop are although very responsive to the higher inputs but it deplete soil fertility. The Integration of green manuring crops along with inorganic fertilizers in the existing cropping system can help to sustain soil fertility and crop productivity. The main objective of the experiment was to assess the effect of green manuring crops on soil fertility and crop productivity. A two years long field experiment was conducted at the Agricultural Research Institute Tarnab, Peshawar-Pakistan. The experiments were laid out in randomized complete block design (RCBD) with split plot arrangement using three replications. A combination of crop species (guar and millet) and crop age at green manuring (40,70 and 100 days after sowing, DAS) were allocated to main plots while the combination of plant parts (whole plant and stubbles) used as green manuring and nitrogen levels (0, 75 and 100 kg ha-1) were applied to sub plots. The two years average data showed that as compared to millet, guar as preceding green manuring crop had significantly improved canola growth, seed yield, oil yield and qualitative traits. Furthermore, based on soil tests, the soil N contents in guar sown plots was significantly higher when tested prior to canola sowing and after canola harvest. The data also revealed that soil C contents in guar sown plots after canola harvest was also significantly higher. Canola sown on the guar green manuring plots had delayed flowering as compared to those green manuring of millet sown plots. Whole plants green manuring as compared to stubbles had significantly enhanced canola growth, yield and yield components and qualitative traits. Based on soil test the soil N contents before canola sowing and after canola harvest and soil C contents after canola harvest were significantly higher in guar incorporated plots as compared to millet plots. Plants that were incorporated at the age of 100 DAS had significantly lower canola growth, yield and yield components, seed N and protein contents as compared with 40 and 70 DAS green manuring. However, the soil C contents of 100 DAS were significantly higher than 40 and 70 DAS green manuring. Although the green manuring at the age of 40 DAS had significantly lower leaf area plant-1 and leaf area index of canola, the other attributes of canola due to age of incorporations (40 DAS) were at par with those of green manuring at the age of 70 DAS. Nitrogen application had significantly affected all the parameters except emergence m-2, seed pod-1 and glucosinolates content. Increasing N level from 0 to 100 kg ha-1 had significantly enhanced growth, yield and yield components and qualitative traits of canola. Nitrogen application at the rate of 75 kg N ha-1 had significantly delayed maturity, having taller plants, more branches plant-1, harvest index, oil yield, and seed protein content as compared with 100 kg N ha-1. Significant Improvement in yield and yield xiii components, quality of canola having taller plants with delayed flowering and maturity were recorded in second year of the experiment as compared with first year. Data on the interaction effect showed significant increase in seed and oil yield of canola with the increase in N levels in both guar and millet sown as preceding green manuring crops irrespective of their age of incorporation. Guar as a green manuring crop had significantly improved yield and quality of canola as compared with millet crop, whole plant green manuring of the crop species at 40 DAS had enhanced seed, oil yield and quality traits followed by 70 DAS. Application of 100 kg N ha-1 along with the green mannuring management had significantly increased all the parameters except oil contents of canola. Data on economic returns showed that guar at 40 DAS incorporation along with 100 kg N ha-1 gave maximum value cost ratio. Our study indicated that green manuring provides an opportunity to improve quantitative and qualitative yield of canola in addition to improving soil health without disturbing the existing cropping system. Hence, it is concluded that green manuring preferably legumes incorporation as whole plant up to the age of 40-70 DAS coupled with 100 kg N ha-1 is recommended for enhancing overall productivity and net economic returns of canola in agro-ecological zones of Khyber Pakhtunkhwa Province, Pakistan and areas alike.
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