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ڈاکٹر عبدالوہاب عزام مصری

ڈاکٹر عبدالوہاب عزام مصری
دوسرا حادثہ دنیائے عرب کی نامور شخصیت ڈاکٹر عبدالوہاب عزام مصری کی وفات کا ہے، وہ عربی دنیا کے اکابررجال میں تھے، ان میں علم و سیاست دونوں کا جتماع تھا علوم و ادب کے فاضل، عربی، فارسی، ترکی، انگریزی، فرنچ وغیرہ متعدد زبانوں کے ماہر تھے، اردو سے بھی واقفیت رکھتے تھے، انہوں نے مصر اور لندن کی یونیورسٹیوں سے ڈاکٹریٹ کی ڈگری حاصل کی تھی، ابتدا میں مدرسہ قضاء شرعی کے استاد مقرر ہوئے تھے، پھر یونیورسٹی میں عربی، فارسی اور ترکی کے پروفیسر، پھر اسی یونیورسٹی میں شعبۂ السنہ مشرقیہ کے صدر مقرر ہوئے، اور آخر میں آرٹس کالج کے پرنسپل ہوگئے تھے، علم کیساتھ سیاست بھی ممتاز تھے، چنانچہ مختلف اوقات میں حکومت مصر کی جانب سے لندن سعودی عرب اور پاکستان کے سفیر مقرر ہوئے، تھوڑے دن ہوئے سعودی حکومت نے ریاض یونیورسٹی کے قیام و تاسیس کے سلسلہ میں ان کی خدمات حاصل کی تھیں، ابھی وہ اس کام کو انجام دے رہے تھے کہ پیام اجل آگیا، انہوں نے اپنے قلم و دماغ سے علم و فن اور دنیائے عرب کی بڑی قیمتی خدمات انجام دیں اور علمی مضامین کے علاوہ بہت سی محققانہ تصانیف اور تراجم یادگار چھوڑے، عربی دنیا میں ان کی موت سے جو جگہ خالی ہوئی ہے وہ مشکل سے بھر سکے گی، اﷲ تعالیٰ علم و ملت کے اس خادم کو اپنے دامن رحمت میں جگہ دے۔
(شاہ معین الدین ندوی، جولائی ۱۹۵۹ء)

 

قضية الانتحال في الشعر الجاهلي عند الاقدمين والمحدثين من الأدباء العرب

This Research Article is based on Plagiarism of the verses in Ancient era of Ignorance (Jahiliat) . The criticism of Ancient and Modem Arabic Poets. The well known literary figure of Arabic Literature put forward the theories and discussion due to which this plagiarism occurred. The next famous commentators who were accused of this sort of plagiarism in Arabic poetry. Beside this the rules and regulations adopted to point out and this practice was put to and end.

Mutational Study of Ns5a Gene in Therapy Resistant Patients Infected With Hepatitis C Genotype 3

Hepatitis C is wide spread infectious disease, affecting almost 185 million people worldwide. It is more prevalent in developing and third world countries, where people have poor health facilities and related education. In Pakistan, nearly 10 million people are affected with HCV and majority of the patients belong to poor class with limited resources for treatment. The available conventional therapy for HCV is not 100% successful and almost 50% patients fail to achieve sustained virological response. The rate of treatment response depends on genetic components of virus and host. The aim of this study was to analyze the host and viral genetic variations associated with interferon and ribavirin therapy in chronic hepatitis C patients. Genetic changes in ISDR and PKRBD region of NS5A gene of HCV and variations of human immune gene IL28B were studied in relation with response to HCV treatment. Total of 220 HCV patients, were enrolled, 100 were responders and 120 were non responders to conventional therapy. The whole blood samples were collected for viral RNA and human DNA extraction. HCV genotype was successfully determined in 60% non-responder patients The viral genomic segments were directly sequenced while IL28B SNPS were analyzed by RFLP. The results showed multiple mutations in ISDR and PKRBD regions of NS5A gene, including two consistent missense variants, A2252V and F2252I. In 74.2% (52/75) of the patients, more than 30 mutations were found in the regions. RFLP analysis of IL28B SNPS revealed that rs12980275 AA (p<0.0001), rs12979860 CT (p=0.001) and rs8099917 TT (p=0.032) genotypes are associated with response to treatment where as AG/GG genotype of rs12980275, CC/TT of rs12979860 and GT/GG of rs8099917 are associated with non response to treatment. The un-typed HCV genotypes were further explored by sequencing 5’UTR region and various nucleotide changes were observed. The results revealed the significant association of rs12980275 polymorphism with treatment response in HCV patients followed by rs12979860 and rs8099917 and various mutations in NS5A gene showed impact on treatment response. These finding may help to predict the response to treatment with IFN in HCV patients and may reduce the side effects and cost of treatment in predicting non-responder patients.
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